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Human FGFR4 Protein, His Tag

Recombinant Human FGFR4 Protein with C-terminal 6XHis tag


Cat.#:  11389

   Size:   100 μg

In Stock

          Product Description          
Cat.#:     11389
Product Name:   Human FGFR4 Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   CD334;JTK2;TKF
Target:    FGFR4
UNIPROT ID:    P22455
Description:    Recombinant Human FGFR4 Protein with C-terminal 6xHis tag
Background:     The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. [provided by RefSeq, Aug 2017]
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 39.3 kDa after removal of the signal peptide.The apparent molecular mass of FGFR4-His is approximately 35-70 kDa due to glycosylation.
Molecular Characterization:    FGFR4(Leu22-Asp369) 6×His Tag
Purity:    The purity of the protein is greater than 90% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human FGFR4 Protein, His Tag on SDS-PAGE under reducing condition.