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Human FZD4 Protein, hFc Tag

Recombinant Human FZD4 with C-terminal human Fc tag


Cat.#:  11414

   Size:   100 μg

In Stock

          Product Description          
Cat.#:     11414
Product Name:   Human FZD4 Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   CD344;EVR1;FEVR;Fz-4;Fz4;FZD4S;FzE4;GPCR;hFz4
Target:    FZD4
Description:    Recombinant Human FZD4 with C-terminal human Fc tag
Background:     This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. [provided by RefSeq, Jul 2008]
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 42.4 kDa after removal of the signal peptide. The apparent molecular mass of FZD4-hFc is approximately 55-70 kDa due to glycosylation.
Molecular Characterization:    FZD4(Phe37-Glu180) hFc(Glu99-Ala330)
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human FZD4 Protein, hFc Tag on SDS-PAGE under reducing condition.