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Human GFRAL Protein, His Tag

Recombinant human GFRAL protein with C-terminal 6XHis tag


Cat.#:  11417

   Size:   100 μg

In Stock

          Product Description          
Cat.#:     11417
Product Name:   Human GFRAL Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   bA360D14.1;C6orf144;GRAL;UNQ9356
Target:    GFRAL
Description:    Recombinant human GFRAL protein with C-terminal 6xHis tag
Background:     Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.[UniProtKB/Swiss-Prot Function]
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 38.6 kDa after removal of the signal peptide. The apparent molecular mass of GFRAL-His is approximately 35-55 kDa due to glycosylation.
Molecular Characterization:    GFRAL(Ser19-Glu351) 6×His tag
Purity:    The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human GFRAL Protein, His Tag on SDS-PAGE under reducing condition.