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Human IGF-1R Protein, His Tag

Recombinant human IGF-1R protein with C-terminal 6XHis tag


Cat.#:  11598

   Size:   100 μg

In Stock

          Product Description          
Cat.#:     11598
Product Name:   Human IGF-1R Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   CD221;IGFIR;IGFR;JTK13
Target:    IGF-1R
UNIPROT ID:    P08069
Description:    Recombinant human IGF-1R protein with C-terminal 6xHis tag
Background:     This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 103.7 kDa after removal of the signal peptide. The apparent molecular mass of IGF-1R-His is approximately 130-150 kDa due to glycosylation.
Molecular Characterization:    IGF-1R(Glu31-Asn932) 6×His tag
Purity:    The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human IGF-1R Protein, His Tag on SDS-PAGE under reducing condition.