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Human IGFBP7 Protein, hFc Tag

Recombinant human IGFBP7 Protein with N-terminal Human Fc tag


Cat.#:  11492

   Size:   100 μg

In Stock

          Product Description          
Cat.#:     11492
Product Name:   Human IGFBP7 Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   IBP-7;TAF;IGFBP-rP1;MAC25 protein
Target:    IGFBP7
UNIPROT ID:    Q16270
Description:    Recombinant human IGFBP7 Protein with N-terminal Human Fc tag
Background:     This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 52.3 kDa after removal of the signal peptide. The apparent molecular mass of hFc-IGFBP7 is approximately 55-70 kDa due to glycosylation.
Molecular Characterization:    hFc(Glu99-Ala330) IGFBP7(Asp30-Leu282)
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human IGFBP7, N-hFc Tag on SDS-PAGE under reducing condition.