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Human IL10 Protein, His Tag

Recombinant Human IL10 protein with N-terminal 6XHis tag


Cat.#:  11824

   Size:   100 μg

In Stock

          Product Description          
Cat.#:     11824
Product Name:   Human IL10 Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   CSIF;GVHDS;IL-10;IL10A;TGIF
Target:    IL10
UNIPROT ID:    P22301
Description:    Recombinant Human IL10 protein with N-terminal 6xHis tag
Background:     The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, May 2020]
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 19.5 kDa after removal of the signal peptide. The apparent molecular mass of His-IL10 is approximately 15-25 kDa due to glycosylation.
Molecular Characterization:    6×His tag IL10(Ser19-Asn178)
Purity:    The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human IL10 Protein, His Tag on SDS-PAGE under reducing condition.