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Human IL12RB1 Protein, His Tag

Recombinant Human IL12RB1 Protein with C-terminal 6XHis tag
5/5

$689.00

Cat.#:  11652

   Size:   100 μg

In Stock

            Product Description          
Cat.#:     11652
Product Name:   Human IL12RB1 Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   CD212;IL-12R-BETA1;IL12RB;IMD30
Target:    IL12RB1
UNIPROT ID:    P42701
Description:    Recombinant Human IL12RB1 Protein with C-terminal 6xHis tag
Background:     The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 57.9 kDa after removal of the signal peptide. The apparent molecular mass of IL12RB1-His is approximately 70-100 kDa due to glycosylation.
Molecular Characterization:    IL12RB1(Cys24-Glu540) 6×His tag
Purity:    The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human IL12RB1 Protein, His Tag on SDS-PAGE under reducing condition.
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