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Human IL17RA Protein, His Tag

Recombinant human IL17RA protein with C-terminal 6XHis tag


Cat.#:  11279

   Size:   100 μg

In Stock

          Product Description          
Cat.#:     11279
Product Name:   Human IL17RA Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   CD217;Dw217;L-17RA;L17R;ANDF5;IL-17R
Target:    IL17RA
Description:    Recombinant human IL17RA protein with C-terminal 6xHis tag
Background:     Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor, IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms.
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 34.3 kDa after removal of the signal peptide.
Molecular Characterization:    IL17RA(Leu33-Trp320) 6×His tag
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human IL17RA Protein, His Tag on SDS-PAGE under reducing condition.

Figure 2. ELISA plate pre-coated by 2 µg/ml (100 µl/well) Human IL17RA, His tagged protein (11279) can bind Anti-IL17RA Neutralizing antibody 28047 in a linear range of 3.2-80 ng/ml.