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Human ITGA2 and ITGB1 Heterodimer Protein, His Tag and hFc Tag

Recombinant human ITGA2 protein with C-terminal 6XHis tag and human ITGB1 protein with C-terminal human Fc tag


Cat.#:  11507

   Size:   100 μg

In Stock

          Product Description          
Cat.#:     11507
Product Name:   Human ITGA2 And ITGB1 Heterodimer Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   Integrin alpha 2 beta 1;TGA2 and ITGB1
Target:    ITGA2 andamp;ITGB1
UNIPROT ID:    P05556
Description:    Recombinant human ITGA2 protein with C-terminal 6xHis tag and human ITGB1 protein with C-terminal human Fc tag
Background:     Integrin alpha 2 beta 1 is one of twelve integrin family adhesion receptors that share the beta 1 subunit. It is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A and Human echoviruses 1 and 8. DGEA inhibited rotavirus binding to alpha2beta1 and infectivity. In a novel process, integrin-using viruses bind the alpha2 I domain of alpha2beta1 via DGE in VP4 and interact with alphaXbeta2 (via GPR) and alphaVbeta3 by using VP7 to facilitate cell entry and infection.
Species/Host:    HEK293
Molecular Weight:    The heterodimer protein has a predicted molecular mass of 121.8 kDa and 104.5 kDa separately after removal of the signal peptide.
Molecular Characterization:    ITGA2(Tyr30-Thr1132) 6×His tag and ITGB1(Gln21-Asp728) hFc(Glu99-Ala330)
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human  ITGA2&ITGB1 Heterodimer Protein, His Tag & hFc Tag on SDS-PAGE under reducing condition.