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Human KIR2DL3 Protein, hFc Tag

Recombinant human KIR2DL3 protein with C-terminal human Fc tag


Cat.#:  11625

   Size:   100 μg

Under development

          Product Description          
Cat.#:     11625
Product Name:   Human KIR2DL3 Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   CD158b;CD158B2;GL183;KIR-023GB;KIR-K7b;KIR-K7c;KIR2DL;KIR2DS5;KIRCL23;NKAT;NKAT2;NKAT2A;NKAT2B;p58
Target:    KIR2DL3
UNIPROT ID:    P43628
Description:    Recombinant human KIR2DL3 protein with C-terminal human Fc tag
Background:     Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 50.16 kDa after removal of the signal peptide.
Molecular Characterization:    KIR2DL3(His22-His245) hFc(Glu99-Ala330)
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.