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Human NTRK1 Protein, hFc Tag

Recombinant Human NTRK1 Protein with C-terminal human Fc tag


Cat.#:  11371

   Size:   100 μg

In Stock

          Product Description          
Cat.#:     11371
Product Name:   Human NTRK1 Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   MTC;p140-TrkA;TRK;Trk-A;TRK1;TRKA
Target:    NTRK1
UNIPROT ID:    P04629
Description:    Recombinant Human NTRK1 Protein with C-terminal human Fc tag
Background:     This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 67.4 kDa after removal of the signal peptide.The apparent molecular mass of NTRK1-hFc is approximately 70-130 kDa due to glycosylation.
Molecular Characterization:    NTRK1(Ala33-Phe410) hFc(Glu99-Ala330)
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human NTRK1 Protein, hFc Tag on SDS-PAGE under reducing condition.