Subtotal:
$347.00
$555.00
| Cat.#: 11150 | ||||
| Product Name: Human OX40 Protein | ||||
| Size : 10 µg, 50 µg and 100 µg | ||||
| Synonyms: TNFRSF4;OX40;CD134;OX40L receptor;ACT35;TXGP1L | ||||
| Target: OX40 | ||||
| UNIPROT ID: P43489 | ||||
| Description: Recombinant human OX40 protein with C-terminal human Fc and 6xHis tag | ||||
| Background: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4 T cell response, as well as in T cell-dependent B cell proliferation and differentiation. | ||||
| Species/Host: HEK293 | ||||
| Molecular Weight: The protein has a predicted molecular mass of 47.2 kDa after removal of the signal peptide. | ||||
| Molecular Characterization: OX40(Leu29-Ala216) hFc(Glu99-Ala330) 6×His tag | ||||
| Purity: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. | ||||
| Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. | ||||
| Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. | ||||
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