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Human RHOB Protein, hFc Tag

Recombinant Human RHOB Protein with C-terminal human Fc tag
5/5

$415.00

Cat.#:  11901

   Size:   100 μg

In Stock

            Product Description          
Cat.#:     11901
Product Name:   Human RHOB Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   ARH6;ARHB;MST081;MSTP081;RHOH6
Target:    RHOB
UNIPROT ID:    P62745
Description:    Recombinant Human RHOB Protein with C-terminal human Fc tag
Background:     Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.[UniProtKB/Swiss-Prot Function]
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 47.4 kDa after removal of the signal peptide. The apparent molecular mass of RHOB-hFc is approximately 35-55 kDa due to glycosylation.
Molecular Characterization:    RHOB(Met1-Gly188) hFc(Glu99-Ala330)
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1.Human RHOB Protein, hFc Tag on SDS-PAGE under reducing condition.
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