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Human RHOC(1-189) Protein, hFc Tag

Recombinant Human RHOC(1-189) Protein with C-terminal human Fc tag


Cat.#:  11902

   Size:   100 μg

In Stock

          Product Description          
Cat.#:     11902
Product Name:   Human RHOC(1-189) Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   ARH9;ARHC;H9;RHOH9
Target:    RhoC
UNIPROT ID:    P08134
Description:    Recombinant Human RHOC(1-189) Protein with C-terminal human Fc tag
Background:     This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 47.7 kDa after removal of the signal peptide. The apparent molecular mass of RHOC(1-189)-hFc is approximately 35-55 kDa due to glycosylation.
Molecular Characterization:    RHOC(Met1-Gly189) hFc(Glu99-Ala330)
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1.Human RHOC(1-189) Protein, hFc Tag on SDS-PAGE under reducing condition.