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Human RSPO3 (22-146) Protein, hFc Tag

Recombinant human RSPO3(22-146) protein with C-terminal human Fc tag


Cat.#:  11467

   Size:   100 μg

In Stock

          Product Description          
Cat.#:     11467
Product Name:   Human RSPO3 (22-146) Protein
Size :    10 µg, 50 µg and 100 µg
Target:    RSPO3
Description:    Recombinant human RSPO3(22-146) protein with C-terminal human Fc tag
Background:     This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development. [provided by RefSeq, Jul 2013]
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 38.6 kDa after removal of the signal peptide. The apparent molecular mass of RSPO3(22-146)-hFc is approximately 35-55 kDa due to glycosylation.
Molecular Characterization:    RSPO3(22-146)(Ser19-Glu351) hFc(Glu99-Ala330)
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human RSPO3(22-146) Protein, hFc Tag on SDS-PAGE under reducing condition.