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Human TIE2 Protein, hFc Tag

Recombinant human TIE2 protein with C-terminal human Fc tag


Cat.#:  11747

   Size:   100 μg

Under development

          Product Description          
Cat.#:     11747
Product Name:   Human TIE2 Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   CD202B;GLC3E;TIE-2;TIE2;VMCM;VMCM1
Target:    TIE2
UNIPROT ID:    Q02763
Description:    Recombinant human TIE2 protein with C-terminal human Fc tag
Background:     This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 105.38 kDa after removal of the signal peptide.
Molecular Characterization:    TIE2 (Trp23-Leu748) hFc(Glu99-ALA330)
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.