Subtotal:
$347.00
$525.00
| Cat.#: 11199 | ||
| Product Name: Human TNFa Protein | ||
| Size : 10 µg, 50 µg and 100 µg | ||
| Synonyms: DIF;NF-alpha;NFA;NFSF2;achexin;achectin;NFa | ||
| Target: TNFA | ||
| UNIPROT ID: P01375 | ||
| Description: Recombinant human TNFa protein with C-terminal 6xHis tag | ||
| Background: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. | ||
| Species/Host: HEK293 | ||
| Molecular Weight: The protein has a predicted molecular mass of 18.1 kDa after removal of the signal peptide. | ||
| Molecular Characterization: TNFa(Val77-Leu233) 6×His tag | ||
| Purity: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. | ||
| Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. | ||
| Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. | ||
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