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Human TNFSF15 Protein, hFc Tag

Recombinant human TNFSF15 protein with N-terminal human Fc tag


Cat.#:  11540

   Size:   100 μg

In Stock

            Product Description          
Cat.#:     11540
Product Name:   Human TNFSF15 Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   TL1;VEGI
Target:    TNFSF15
UNIPROT ID:    O95150
Description:    Recombinant human TNFSF15 protein with N-terminal human Fc tag
Background:     The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 46.6 kDa after removal of the signal peptide. The apparent molecular mass of hFc-TNFSF15 is approximately 35-55kDa due to glycosylation.
Molecular Characterization:    hFc(Glu99-Ala330) TNFSF15(Leu72-Leu251)
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human TNFSF15 Protein, N-hFc Tag on SDS-PAGE under reducing condition.