Email:   |  Call: 6109452007

IL1B (DMC271) IgG1 Chimeric mAb

Anti-IL1B (DMC271) IgG1 Chimeric Monoclonal Antibody


Cat.#:  28179

   Size:   100 μg

In Stock

          Product Description          
Cat.#:   28179
Product Name:   Anti-IL1B(DMC271) IgG1 Chimeric Monoclonal Antibody
Synonyms:   IL-1; IL1-BETA; IL1F2
Description:    Anti-IL1B antibody(DMC271) IgG1 Chimeric Monoclonal Antibody
Background:    The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein; which is proteolytically processed to its active form by caspase 1 (CASP1:ICE). This cytokine is an important mediator of the inflammatory response; and is involved in a variety of cellular activities; including cell proliferation; differentiation; and apoptosis. The induction of cyclooxygenase-2 (PTGS2:COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly; IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent; a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
Applications:    Flow Cyt
Recommended Dilutions:    Flow Cyt 1:100
Host Species:    Rabbit
Isotype:    Rabbit:Human Fc chimeric IgG1
Purification:    Purified from cell culture supernatant by affinity chromatography
Species Reactivity:    Human IL1B
Constituents:    Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Figure 1. Flow cytometry analysis with Anti-IL1B (DMC271) on Expi293 cells transfected with human IL1B (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).