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LILRB2 (DMC496) IgG1 Chimeric mAb

Anti-LILRB2 (DMC496) IgG1 Chimeric Monoclonal Antibody


Cat.#:  28269

   Size:   100 μg

In Stock

          Product Description          
Cat.#:   28269
Product Name:   Anti-LILRB2(DMC496) IgG1 Chimeric Monoclonal Antibody
Synonyms:   LIR-2; ILT-4; MIR-10; CD85d
Description:    Anti-LILRB2 antibody(DMC496) IgG1 Chimeric Monoclonal Antibody
Background:    This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family; which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains; a transmembrane domain; and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq; Jul 2008]
Applications:    Flow Cyt
Recommended Dilutions:    Flow Cyt 1:100
Host Species:    Rabbit
Isotype:    Rabbit:Human Fc chimeric IgG1
Purification:    Purified from cell culture supernatant by affinity chromatography
Species Reactivity:    Human LILRB2
Constituents:    Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Figure 1. Flow cytometry analysis with Anti-LILRB2 (DMC496) on Expi293 cells transfected with human LILRB2 (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).