Subtotal:
$347.00
$4,400.00
| Cat.#: 11086 | ||
| Product Name: Human MRGPRX2 Full Length Protein | ||
| Size : 10 µg; 50 µg and 100 µg | ||
| Synonyms: MGRG3; MRGX2 | ||
| Target: MRGPRX2 | ||
| UNIPROT ID: Q96LB1 | ||
| Description: Human MRGPRX2 Full Length Protein-Synthetic Nanodisc | ||
| Background: Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction. Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A. | ||
| Species/Host: HEK293 | ||
| Molecular Weight: The human full length MRGPRX2 protein has a MW of 37.1 kDa | ||
| Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. | ||
| Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. | ||
| Protein Families: Druggable Genome, GPCR, Transmembrane | ||
| Protein Pathways: N.A. | ||
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