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Nectin4 (DMC438) IgG1 Chimeric mAb

Anti-Nectin4 (DMC438) IgG1 Chimeric Monoclonal Antibody


Cat.#:  28226

   Size:   100 μg

In Stock

          Product Description          
Cat.#:   28226
Product Name:   Anti-Nectin4(DMC438) IgG1 Chimeric Monoclonal Antibody
Synonyms:   EDSS1; LNIR; nectin-4; PRR4; PVRL4
Description:    Anti-Nectin4 antibody(DMC438) IgG1 Chimeric Monoclonal Antibody
Background:    This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17:TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1; an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.
Applications:    Flow Cyt
Recommended Dilutions:    Flow Cyt 1:100
Host Species:    Rabbit
Isotype:    Rabbit:Human Fc chimeric IgG1
Purification:    Purified from cell culture supernatant by affinity chromatography
Species Reactivity:    Human NECTIN4
Constituents:    Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Figure 1. Flow cytometry analysis with Anti-Nectin4 (DMC438) on Expi293 cells transfected with human Nectin4 (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).