NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$495.00
Cat. #: 26192 |
Gene Symbol: Ras(Q61R) |
Description: Anti-Ras(Q61R) Mouse Monoclonal Antibody |
Background: Ras protein is a membrane associated GTPase signaling protein that regulates proliferation, differentiation, and cell survival. Ras Q61R mutation result in decreased GTPase activity and constitutive signaling, and is correlated with the development of pancreatic intraepithelial neoplasia and lung lesions. |
Immunogen: A synthetic peptide from the internal region of Ras which includes the mutation of Q61R, human origin. |
Applications: ELISA, WB, IHC |
Recommended Dilutions: ELISA 1:100-1:5000 WB 1:100-1:1000 IHC 1:50-1:100 |
Concentration: 1 mg/ml |
Host Species: Mouse |
Format: Liquid |
Clonality: Monoclonal |
Isotype: IgG |
Purity: Purified from ascites |
Preservative: No |
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
Species Reactivity: Recognizes Ras(Q61R), but not wild type Ras protein from vertebrates. |
Storage Conditions: Store at -20°C. Avoid repeated freezing and thawing |
Western blot: Western blot analysis of recombinant Ras WT and Q61R proteins. Equal amount of purified Ras WT and Q61R proteins were loaded and blotted with anti-Ras(Q61R) mouse monoclonal antibody (Cat. # 26192). |