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EGFR(E746-A750)del

Anti-EGFR(E746-A750)del Mouse Monoclonal Antibody
5/5

$495.00

Cat.#:  26235

   Size:   100 μl

In Stock

          Product Description          

EGFR(E746-A750)del

Cat. #:   26235
Gene Symbol:  EGFR/HER1/ERBB1
Description:   Anti-EGFR(E746-A750)del Mouse Monoclonal Antibody
Background:   EGFR is a receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. It activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. Defects in EGFR are associated with lung cancer (LNCR).
Immunogen:   A synthetic peptide from the internal region of EGFR which includes the deletion of E746-A750, human origin.
Applications:   ELISA, WB
Recommended Dilutions:   
ELISA: 1:1000-1:5000
WB: 1:500-1:1000
Concentration:   1 mg/ml
Host Species:   Mouse
Format:   Liquid
Clonality:   Monoclonal
Isotype:   
Purity:   Purified from ascites
Preservative: No
Constituents:  PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
Species Reactivity:  Recognizes EGFR(E746-A750), but not wild type EGFR of vertebrates.
Storage Conditions:   Store at -20°C. Avoid freeze/thaw cycles

Western blot:  

Western blot analysis of recombinant EGFR(E746-A750) and wild type proteins.

Purified His-tagged EGFR(E746-A750)del protein (aa 702-987) and wild type protein (aa 702-987) were blotted with anti- EGFR(E746-A750)del mouse antibody (Cat. #26235).

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