PTEN (R130G) Cat. #:  26312 Gene Symbol: PTEN, 10q23del, BZS, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1, MMAC1, PTEN1, TEP1 Description: Anti-PTEN (R130G) Mouse Monoclonal Antibody Background: Phosphatase and tensin homolog (PTEN) was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency.I t is one of the most commonly lost tumor suppressors in human cancer. During tumor development, mutations and deletions of PTEN occur that inactivate its enzymatic activity leading to increased cell proliferation and reduced cell death. Frequent genetic inactivation of PTEN occurs in glioblastoma, endometrial cancer,and prostate cancer; and reduced expression is found in many other tumor types such as lung and breast cancer. Immunogen: A synthetic peptide from the internal region of PTEN which includes the mutation of R130G, human origin. Tested applications: ELISA, WB Recommended dilutions: ELISA:  1:1000-1:5000 WB:     1:500-1:1000 Concentration: 1 mg/ml Host Species: Mouse Clonality: Monoclonal Purity: Purified from ascites Format: Liquid Storage buffer:  Preservative: no Constituents: PBS (without Mg2+ and Ca2+),pH 7.4, 150 mM NaCl, 50% glycerol Species Reactivity: Recognizes R130G mutant,but not wild type PTEN from vertebrates. Storage Conditions: Store at -20°C. Avoid Western blot: Western blot analysis of recombinant PTEN R130G) and wild type proteins. Purified His-tagged FGFR1 (R130G) protein (lane 2) and corresponding wild type protein (lane 1) were blotted with anti-PTEN (R130G) monoclonal antibody (Cat. #26312).