NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$495.00
FGFR1 Nterminal Monoclonal Antibody
Cat. #: 26386 |
Gene Symbol: FGFR1, BFGFR, CD331, CEK, FGFBR, FLG |
Description: Anti-FGFR1 Nterminal Mouse Monoclonal Antibody |
Background: The protein FGFR1 is highly conserved between members and throughout evolution. This particular family member of FGFR1 binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations of FGFR1 protein have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, squamous cell lung cancer and autosomal dominant Kallmann syndrome. |
Immunogen: A synthetic peptide from the Nterminal region of FGFR1, human origin. |
Applications: ELISA, WB, IHC |
Recommended Dilutions: ELISA: 1:1000-1:2000 WB: 1:500-1:1000 IHC: 1:50-1:100 |
Concentration: 1 mg/ml |
Host Species: Mouse |
Format: Liquid |
Clonality: Monoclonal |
Isotype: IgG |
Purity: Purified from ascites |
Preservative: No |
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
Species Reactivity: Recognizes N-Termina (22-376aa) and full-length FGFR1 of vertebrates. |
Storage Conditions: Store at -20°C. Avoid repeated freezing and thawing |
Western blot: Western blot analysis of recombinant FGFR1 NTerminal protein. Purified His-tagged FGFR1 NTerminal protein (22-376aa, 45KD) was blotted with Anti-FGFR1 NTerminal monoclonal antibody (Cat. #26386). Immunofluorescence: Immunofluorescence of cells expressing FGFR1 N-terminal proteins with Anti-FGFR1 N-terminal antibody. HEK293T cells were transfected with pCDNA3-GFP-FGFR1 N Terminal plasmid, then fixed and stained with Anti-FGFR1 N Terminal monoclonal antibody (Cat. #26386). |