NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$239.00
survivin Monoclonal Antibody
Cat. #: 26131 |
Gene Symbol: BIRC5; API4; EPR-1 |
Description: anti-survivin Mouse Monoclonal Antibody |
Background: Survivin is a member of the inhibitor of apoptosis (IAP) family. The survivin protein negatively regulate of programmed cell death by inhibiting caspase. Survivin protein is high expressed in most human tumors and fetal tissue, but is absent in differentiated cells. This makes survivin an ideal target for cancer therapy. Survivin is only expressed in the G2-M phase cells. It also plays a role in regulating mitosis. |
Immunogen: Purified survivin protein, human origin. |
Applications: ELISA, WB, IHC |
Recommended Dilutions: ELISA: 1:1000-1:5000 WB: 1:100-1:1000 IHC: 1:50-1:200 |
Concentration: 1mg/ml |
Host Species: Mouse |
Format: Liquid |
Clonality: Monoclonal |
Isotype: IgG |
Purity: Purified from ascites |
Preservative: No |
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
Species Reactivity: Recognizes survivin of vertebrates. |
Storage Conditions: Store at -20°C. Avoid repeated freezing and thawing |
Western blot: Purified His-tagged Survivin protein was blotted with anti survivin mouse monoclonal antibody (Cat. #26131). Immunohistochemistry: |