Email: info@neweastbio.com   |  Call: 6109452007

CD162 (DMC283) IgG1 Chimeric mAb

Anti-CD162 (DMC283) IgG1 Chimeric Monoclonal Antibody
5/5

$445.00

Cat.#:  28191

   Size:   100 μg

In Stock

          Product Description          
Cat.#:   28191
Product Name:   Anti-CD162(DMC283) IgG1 Chimeric Monoclonal Antibody
Synonyms:   PSGL-1;PSGL1;CD162;SELPLG;Selectin P ligand
Description:    Anti-CD162 antibody(DMC283) IgG1 Chimeric Monoclonal Antibody
Background:    This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-; E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such; this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications; tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans; for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.
Applications:    Flow Cyt
Recommended Dilutions:    Flow Cyt 1:100
Host Species:    Rabbit
Isotype:    Rabbit:Human Fc chimeric IgG1
Purification:    Purified from cell culture supernatant by affinity chromatography
Species Reactivity:    Human CD162
Constituents:    Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Figure 1. Flow cytometry analysis with Anti-CD162 (DMC283) on Expi293 cells transfected with human CD162 (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).
          Publications