Email: info@neweastbio.com   |  Call: 6109452007

MDC1 Rabbit pAb

Anti-MDC1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S213896

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S213896
Product Name:   Anti-MDC1 Rabbit Polyclonal Antibody
Synonyms:   NFBD1
UNIPROT ID:   Q14676 (Gene Accession – NP_055456 )
Background:    The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
Immunogen:    Synthetic peptide of human MDC1
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 100-300; ELISA: 2000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human brain tissue using 213896(MDC1 Antibody) at a dilution of 1/80(Cytoplasm, Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human brain tissue is first treated with the synthetic peptide and then with 213896(Anti-MDC1 Antibody) at dilution 1/80.
          Publications