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POLH Rabbit pAb

Anti-POLH Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S218876

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S218876
Product Name:   Anti-POLH Rabbit Polyclonal Antibody
Synonyms:   XPV; XP-V; RAD30; RAD30A
UNIPROT ID:   Q9Y253 (Gene Accession – BC015742 )
Background:    This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene.
Immunogen:    Fusion protein of human POLH
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-300; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human esophagus cancer tissue using 218876(POLH Antibody) at a dilution of 1/60(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human esophagus cancer tissue is first treated with the fusion protein and then with 218876(Anti-POLH Antibody) at dilution 1/60.

The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using 218876(Anti-POLH Antibody) at a dilution of 1/60.

In comparision with the IHC on the left, the same paraffin-embedded Human breast cancer tissue is first treated with fusion protein and then with D225422(Anti-POLH Antibody) at dilution 1/60.
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