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ENPP7 Rabbit pAb

Anti-ENPP7 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S219760

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S219760
Product Name:   Anti-ENPP7 Rabbit Polyclonal Antibody
Synonyms:   ALK-SMase
UNIPROT ID:   Q6UWV6 (Gene Accession – NP_848638 )
Background:    Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 (E-NPP 7) also known as alkaline sphingomyelin phosphodiesterase (Alk-SMase) or intestinal alkaline sphingomyelinase is an enzyme that in humans is encoded by the ENPP7 gene. Converts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine. Does not appear to have nucleotide pyrophosphatase activity. Inhibited in a dose dependent manner by ATP, imidazole, orthovanadate and zinc ion. Not inhibited by ADP, AMP and EDTA. Detected in the colon (at protein level). Expressed in the duodenum, jejunum and liver and at low levels in the ileum. Expression was very low in the esophagus, stomach and colon.
Immunogen:    Synthetic peptide of human ENPP7
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 25-100; ELISA: 1000-2000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling, Cancer
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human prostate cancer tissue using 219760(ENPP7 Antibody) at a dilution of 1/40(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human prostate cancer tissue is first treated with the synthetic peptide and then with 219760(Anti-ENPP7 Antibody) at dilution 1/40.

The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using 219760(Anti-ENPP7 Antibody) at a dilution of 1/40.

In comparision with the IHC on the left, the same paraffin-embedded Human colon cancer tissue is first treated with synthetic peptide and then with D260300(Anti-ENPP7 Antibody) at dilution 1/40.
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