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UHRF1 Rabbit mAb

Anti-UHRF1 Rabbit Monoclonal Antibody
5/5

$349.00

Cat.#:  N261599

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N261599
Product Name:   Anti-UHRF1 Rabbit Monoclonal Antibody
Synonyms:   Np95; hNP95; ICBP90; RNF106
UNIPROT ID:   Q96T88
Background:    This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.
Immunogen:    Recombinant protein of human UHRF1
Applications:    WB,IP
Recommended Dilutions:    WB: 1/500-1/1000 IP: 1/20
Host Species:    Rabbit
Clonality:    Rabbit Monoclonal
Clone ID:    R06-1C4
MW:    Calculated MW: 90 kDa; Observed MW: 97 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Human
Conjugation:    Unconjugated
Modification:    Unmodified
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Western blot analysis of UHRF1 in K562, Hela lysates using UHRF1 antibody.
          Publications