$349.00
Cat.#: N262439 |
Product Name: Anti-kappa Opioid Receptor Rabbit Monoclonal Antibody |
Synonyms: KOR; R21; KOR-1; MSL-1; Oprk2; K-OR-1 |
UNIPROT ID: P33534 |
Background: G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. |
Immunogen: A synthetic peptide of mouse Kappa Opioid Receptor |
Applications: WB,IP |
Recommended Dilutions: WB: 1/500-1/1000 IP: 1/20 |
Host Species: Rabbit |
Clonality: Rabbit Monoclonal |
Clone ID: R03-2A5 |
MW: Calculated MW: 43 kDa; Observed MW: 60 kDa |
Isotype: IgG |
Purification: Affinity Purified |
Species Reactivity: Rat |
Conjugation: Unconjugated |
Modification: Unmodified |
Constituents: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide |
Research Areas: Neuroscience |
Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing |
Western blot analysis of Kappa Opioid Receptor in rat Brain lysates using kappa Opioid Receptor antibody. |