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APC Rabbit mAb

Anti-APC Rabbit Monoclonal Antibody
5/5

$349.00

Cat.#:  N263222

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N263222
Product Name:   Anti-APC Rabbit Monoclonal Antibody
Synonyms:   APC; DP2.5; Adenomatous polyposis coli protein; Protein APC; Deleted in polyposis 2.5
UNIPROT ID:   P25054
Background:    Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.
Immunogen:    A synthetic peptide of human APC
Applications:    WB,ICC/IF,IP
Recommended Dilutions:    WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20
Host Species:    Rabbit
Clonality:    Rabbit Monoclonal
Clone ID:    R06-2E4
MW:    Calculated MW: 312 kDa; Observed MW: 160 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Human
Conjugation:    Unconjugated
Modification:    Unmodified
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Cell Biology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Western blot analysis of APC in Hela, A549, HL-60, U2OS lysates using APC antibody.

Immunocytochemistry analysis of APC (green) in LNcap using APC antibody,and DAPI(blue).
          Publications