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Daxx Rabbit mAb

Anti-Daxx Rabbit Monoclonal Antibody
5/5

$349.00

Cat.#:  N263297

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N263297
Product Name:   Anti-Daxx Rabbit Monoclonal Antibody
Synonyms:   DAXX; BING2; DAP6; Death domain-associated protein 6; Daxx; hDaxx; ETS1-associated protein 1; EAP1; Fas death domain-associated protein
UNIPROT ID:   Q9UER7
Background:    Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted.
Immunogen:    A synthetic peptide of human Daxx
Applications:    WB,ICC/IF
Recommended Dilutions:    WB: 1/500-1/1000 IF: 1/50-1/200
Host Species:    Rabbit
Clonality:    Rabbit Monoclonal
Clone ID:    R07-7F4
MW:    Calculated MW: 81 kDa; Observed MW: 110 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Human
Conjugation:    Unconjugated
Modification:    Unmodified
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Cell Biology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Western blot analysis of Daxx in HepG2, U251, HL-60 lysates using Daxx antibody.

Immunocytochemistry analysis of Daxx (green) in K562 using Daxx antibody,and DAPI(blue).
          Publications