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02. Lung cancer cell-intrinsic IL-15 promotes cell migration and sensitizes murine lung tumors to anti-PD-L1 therapy
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03. A Natural Small Molecule Mitigates Kidney Fibrosis by Targeting Cdc42‐mediated GSK‐3β/β‐catenin Signaling
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04. Infiltrative vessel co-optive growth pattern induced by IQGAP3 overexpression promotes microvascular invasion in hepatocellular carcinoma
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05. 25-hydroxycholesterol inhibits human papillomavirus infection in cervical epithelial cells by perturbing cytoskeletal remodeling
J Med Virol. 2023 PMID: 37254637 |
06. Lithium impacts the function of hematopoietic stem cells via disturbing the endoplasmic reticulum stress and Hsp90 signaling
Food Chem Toxicol. 2023 PMID: 37783420 |
07. The activated CD36-Src axis promotes lung adenocarcinoma cell proliferation and actin remodeling-involved metastasis in high-fat environment
Cell Death Dis. 2023 PMID: 37612265 |
08. Glutamine metabolic microenvironment drives M2 macrophage polarization to mediate trastuzumab resistance in HER2‐positive gastric cancer
Cancer Commun (Lond). 2023 PMID: 37434399 |
09. Cystic fibrosis macrophage function and clinical outcomes after elexacaftor/tezacaftor/ivacaftor
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10. ARHGEF37 overexpression promotes extravasation and metastasis of hepatocellular carcinoma via directly activating Cdc42
J Exp Clin Cancer Res. 2022 PMID: 35869555 |
11. C9orf72 knockdown alleviates hepatic insulin resistance by promoting lipophagy
Biochem Biophys Res Commun. 2022 PMID: 34942529 |
12. Novel rapid immunohistochemistry using an alternating current electric field identifies Rac and Cdc42 activation in human colon cancer FFPE tissues
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13. Novel rapid immunohistochemistry using an alternating current electric field identifies Rac and Cdc42 activation in human colon cancer FFPE tissues
Sci Rep. 2022 PMID: 35110666 |
14. Arhgef6 (alpha-PIX) cytoskeletal regulator signals to GTPases and Cofilin to couple T cell migration speed and persistence
J Leukoc Biol. 2021 PMID: 33527537 |
15. Glucocorticoid-mediated induction of caveolin-1 disrupts cytoskeletal organization.inhibits cell migration and re-epithelialization of non-healing wounds
Commun Biol. 2021 PMID: 34145387 |
16. NDRG1 regulates Filopodia-induced Colorectal Cancer invasiveness via modulating CDC42 activity
Int J Biol Sci. 2021 PMID: 33994856 |
17. Spatiotemporal Control of Actomyosin Contractility by MRCKß Signaling Drives Phagocytosis
bioRxiv,2021 PMID: 36121394 |
18. Cdc42 Mediates Cancer Cell Chemotaxis in Perineural Invasion
Mol Cancer Res. 2020 PMID: 32086369 |
19. Mevalonate metabolismûdependent protein geranylgeranylation regulates thymocyte egress
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20. Progressive Pulmonary Fibrosis Is Caused by Elevated Mechanical Tension on Alveolar Stem Cells
Cell. 2020 PMID: 31866069 |
21. Spatial distribution of IL4 controls iNKT cell-DC crosstalk in tumors
Cell Mol Immunol. 2020 PMID: 31160756 |
22. Cdc42 is involved in NC1 peptideûregulated BTB dynamics through actin and microtubule cytoskeletal reorganization
FASEB J. 2019 PMID: 31682474 |
23. Effects of age-dependent changes in cell size on endothelial cell proliferation and senescence through YAP1
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24. Inhibition of Cdc42-intersectin interaction by small molecule ZCL367 impedes cancer cell cycle progression.proliferation.migration.and tumor growth
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25. Inhibition of Fascin in Cancer and Stromal Cells Blocks Ovarian Cancer Metastasis
Gynecol Oncol. 2019 PMID: 30797592 |
26. Sertoli cell–specific coxsackievirus and adenovirus receptor regulates cell adhesion and gene transcription via β-catenin inactivation and Cdc42 activation
FASEB J..2019 PMID: 30892947 |
27. The alteration of RhoA geranylgeranylation and Ras farnesylation breaks the integrity of the bloodûtestis barrier and results in hypospermatogenesis
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28. WiskottûAldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma
Nat Med. 2019 PMID: 30510251 |
29. Cadmium Activates Noncanonical Wnt Signaling to Impair Hematopoietic Stem Cell Function in Mice
Toxicol Sci.2018 PMID: 29939372 |
30. Integrating transient cellular and nuclear motions to comprehensively describe cell migration patterns
Sci Rep. 2018 PMID: 29367613 |
31. MiR-142-3p Inhibits TGF-β3-Induced Blood-Testis Barrier Impairment by Targeting Lethal Giant Larvae Homolog 2
Cell Physiol Biochem. 2018 PMID: 29590647 |
32. A FAK-YAP-mTOR signaling axis regulates stem cell-based tissue renewal in mice
Cell Stem Cell. 2017 PMID: 28457749 |
33. Curcumin inhibits growth of human breast cancer cells through demethylation of DLC1 promoter
Mol Cell Biochem..2017 PMID: 27830358 |
34. GGPP-Mediated Protein Geranylgeranylation in Oocyte Is Essential for the Establishment of Oocyte-Granulosa Cell Communication and Primary-Secondary Follicle Transition in Mouse Ovary
PLoS Genet. 2017 PMID: 28072828 |
35. Heme oxygenase-1 protects spinal cord neurons from hydrogen peroxide-induced apoptosis via suppression of Cdc42/MLK3/MKK7/JNK3 signaling
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36. High glucose levels promote the proliferation of breast cancer cells through GTPases
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37. microRNA-206 modulates an Rtn4a/Cxcr4a/Thbs3a axis in newly forming somites to maintain and stabilize the somite boundary formation of zebrafish embryos
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38. Myosin 1g Contributes to CD44 Adhesion Protein and Lipid Rafts Recycling and Controls CD44 Capping and Cell Migration in B Lymphocytes
Front Immunol. 2017 PMID: 29321775 |
39. Primary angle closure glaucoma (PACG) susceptibility gene PLEKHA7 encodes a novel Rac1/Cdc42 GAP that modulates cell migration and blood-aqueous barrier function
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40. PTEN controls glandular morphogenesis through a juxtamembrane ß-Arrestin1/ARHGAP21 scaffolding complex
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41. Mutations of Cystic Fibrosis Transmembrane Conductance Regulator Gene Cause a Monocyte-Selective Adhesion Deficiency
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42. Nitric oxide increases the migratory activity of non-small cell lung cancer cells via AKT-mediated integrin αv and β1 upregulation
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43. Opposing effects of actin signaling and LFA-1 on establishing the affinity threshold for inducing effector T-cell responses in mice
Eur J Immunol. 2016 PMID: 27188212 |
44. Thiopurine Prodrugs Mediate Immunosuppressive Effects by Interfering with Rac1 Protein Function
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45. Actin remodeling by Nck regulates endothelial lumen formation
Mol Biol Cell. 2015 PMID: 26157164 |
46. Axon Targeting of the Alpha 7 Nicotinic Receptor in Developing Hippocampal Neurons by Gprin1 Regulates Growth
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47. Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation
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48. Loss of ARHGDIA expression is associated with poor prognosis in HCC and promotes invasion and metastasis of HCC cells
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49. MIF inhibits monocytic movement through a non-canonical receptor and disruption of temporal Rho GTPase activities in U-937 cells
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50. Spatial control of Cdc42 signalling by a GM130-RasGRF complex regulates polarity and tumorigenesis
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51. srGAP3 promotes neurite outgrowth of dorsal root ganglion neurons by inactivating RAC1
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52. The a4 Nicotinic Receptor Promotes CD4+ T-Cell Proliferation and a Helper T-Cell Immune Response
Mol Pharmacol..2014 PMID: 24107512 |
53. The Cdc42 Guanine Nucleotide Exchange Factor FGD6 Coordinates Cell Polarity and Endosomal Membrane Recycling in Osteoclasts
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54. The tumour suppressor DLC2 ensures mitotic fidelity by coordinating spindle positioning and cellûcell adhesion
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55. Depletion of the transcriptional coactivators megakaryoblastic leukaemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence
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56. p21-Activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils
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57. Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex
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58. Essential Role for Rac1 in Cocaine-Induced Structural Plasticity of Nucleus Accumbens Neurons
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59. Invadopodia and rolling-type motility are specific features of highly invasive p190(bcr-abl) leukemic cells
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60. ProBDNF Collapses Neurite Outgrowth of Primary Neurons by Activating RhoA
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61. Enterohemorrhagic Escherichia coli infection stimulates Shiga toxin 1 macropinocytosis and transcytosis across intestinal epithelial cells
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62. Polarized migration of lymphatic endothelial cells is critically dependent on podoplanin regulation of Cdc42
Am J Physiol Lung Cell Mol Physiol. 2011 PMID: 21036919 |
63. The Aarskog-Scott Syndrome Protein Fgd1 Regulates Podosome Formation and Extracellular Matrix Remodeling in Transforming Growth Factor á-Stimulated Aortic Endothelial Cells
Mol Cell Biol. 2011 PMID: 21911474 |
Purified recombinant Cdc42 proteins were loaded with GDP (lane 1) or GTPγS (lane 2). These proteins were immunoprecipitated with anti-Cdc42-GTP mouse monoclonal antibody (Cat. # 26905). After SDS/PAGE, the membrane filter was probed with anti-Cdc42 mouse monoclonal antibody (Cat. # 26008).
Immunofluorescent labeling of Cdc42-GTP in MS1 mouse endothelial cells. The MS1 cells cultured on glass coverslips (Fisher) in DMEM containing 5% FBS were fixed with 4% paraformaldehyde for 10 minutes at RT (room temperature) and permeabilized in PBSN (PBS+0.1%NP40) for 15 minutes at RT. The cells were stained with primary antibody (Cdc42-GTP) at 1:25 dilution in Invitrogen’s CAS-BLOCK (00-8120) reagent at RT for 1 hour. After brief washing in PBSN (3x5min), a secondary Alexa555 conjugated goat anti mouse antibody (Invitrogen A21424) was applied in 1:200 in CAS-BLOCK at RT for 1 hour. The coverslips were then washed in PBSN (3x5min) and mounted using vectorsheld’s hard set mounting medium (H-1500), and examined using a Zeiss inverted fluorescence microscope.
Immunofluorescence staining of h-iNPCE cells with anti-Cdc42GTP mAbs shown as red
Immunofluorescence staining of HCE cells with anti-Cdc42GTP mAbs
