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Human ADGRE5 Full Length Protein

Human ADGRE5 Full Length Protein-Synthetic Nanodisc
5/5

$4,400.00

Cat.#:  11098

   Size:   50 μg

In Stock

          Product Description          
Cat.#:     11098
Product Name:   Human ADGRE5 Full Length Protein
Size :    10 µg; 50 µg and 100 µg
Synonyms:   CD97; TM7LN1
Target:    ADGRE5
UNIPROT ID:    P48960
Description:    Human ADGRE5 Full Length Protein-Synthetic Nanodisc
Background:     A member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19.
Species/Host:    HEK293
Molecular Weight:    The human full length ADGRE5 protein has a MW of 90.5 kDa
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Protein Families:    Druggable Genome, GPCR, Transmembrane
Protein Pathways:    N/A

Figure 1. Elisa plates were pre-coated with Flag Tag ADGRE5-Nanodisc (0.2μg/per well). Serial diluted anti-Flag monoclonal antibody solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-Flag monoclonal antibody binding with ADGRE5-Nanodisc is 7.327ng/ml.

Figure 2. Human ADGRE5-Nanodisc, Flag Tag on SDS-PAGE
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