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Aprataxin Rabbit mAb

Anti-Aprataxin Rabbit Monoclonal Antibody
5/5

$349.00

Cat.#:  N261862

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N261862
Product Name:   Anti-Aprataxin Rabbit Monoclonal Antibody
Synonyms:   AOA; AOA1; AXA1; EAOH; EOAHA; FHA-HIT
UNIPROT ID:   Q7Z2E3
Background:    DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair (PubMed:15380105, PubMed:15044383, PubMed:16964241, PubMed:17276982, PubMed:24362567). Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species (PubMed:16964241, PubMed:24362567). Catalyzes the release of adenylate groups covalently linked to 5′-phosphate termini, resulting in the production of 5′-phosphate termini that can be efficiently rejoined (PubMed:16964241, PubMed:17276982, PubMed:24362567). Also able to hydrolyze adenosine 5′-monophosphoramidate (AMP-NH2) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (PubMed:16547001). Likewise, catalyzes the release of 3′-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5′-linked adenosine (AppDNA) .
Immunogen:    A synthetic peptide of human Aprataxin
Applications:    WB,ICC/IF
Recommended Dilutions:    WB: 1/500-1/1000 IF: 1/50-1/200
Host Species:    Rabbit
Clonality:    Rabbit Monoclonal
Clone ID:    R03-9F6
MW:    Calculated MW: 41 kDa; Observed MW: 41 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Human
Conjugation:    Unconjugated
Modification:    Unmodified
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Western blot analysis of Aprataxin in K562, Hela lysates using Aprataxin antibody.

Immunocytochemistry analysis of Aprataxin (green) in U87-MG using Aprataxin antibody,and DAPI(blue).
          Publications