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BIN1 Rabbit mAb

Anti-BIN1 Rabbit Monoclonal Antibody
5/5

$349.00

Cat.#:  N261925

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N261925
Product Name:   Anti-BIN1 Rabbit Monoclonal Antibody
Synonyms:   BIN1; AMPHL; Myc box-dependent-interacting protein 1; Amphiphysin II; Amphiphysin-like protein; Box-dependent myc-interacting protein 1; Bridging integrator 1
UNIPROT ID:   O00499
Background:    This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
Immunogen:    Recombinant protein of human BIN1
Applications:    WB,IHC-F,IHC-P,ICC/IF
Recommended Dilutions:    WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200
Host Species:    Rabbit
Clonality:    Rabbit Monoclonal
Clone ID:    R07-2C1
MW:    Calculated MW: 65 kDa; Observed MW: 45-80 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Human,Mouse,Rat
Conjugation:    Unconjugated
Modification:    Unmodified
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Cell Biology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Western blot analysis of BIN1 in rat Brain lysates using BIN1 antibody

Immunocytochemistry analysis of BIN1 (green) in U87-MG using BIN1 antibody,and DAPI(blue).

Western blot analysis of BIN1 in rat brain, mouse muscle lysates using BIN1 antibody.

Immunohistochemistry analysis of paraffin-embedded Human tonsil using BIN1 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
          Publications