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CCND1 Rabbit pAb

Anti-CCND1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S213467

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S213467
Product Name:   Anti-CCND1 Rabbit Polyclonal Antibody
Synonyms:   BCL1, PRAD1, U21B31, D11S287E
UNIPROT ID:   P24385 (Gene Accession – BC000076 )
Background:    The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
Immunogen:    Synthetic peptide of human CCND1
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: Oct-50; ELISA: 500-5000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling, Cancer
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human breast cancer tissue using 213467(CCND1 Antibody) at a dilution of 1/25(Cytoplasm, Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human breast cancer tissue is first treated with the synthetic peptide and then with 213467(Anti-CCND1 Antibody) at dilution 1/25.

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 213467(Anti-CCND1 Antibody) at a dilution of 1/25.

In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with synthetic peptide and then with D160236(Anti-CCND1 Antibody) at dilution 1/25.
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