NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$349.00
Cat.#: N262067 |
Product Name: Anti-CRM1 Rabbit Monoclonal Antibody |
Synonyms: XPO1; CRM1; Exportin-1; Exp1; Chromosome region maintenance 1 protein homolog |
UNIPROT ID: O14980 |
Background: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. |
Immunogen: A synthetic peptide of human CRM1 |
Applications: WB,IHC-F,IHC-P,ICC/IF |
Recommended Dilutions: WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 |
Host Species: Rabbit |
Clonality: Rabbit Monoclonal |
Clone ID: R01-9J7 |
MW: Calculated MW: 123 kDa; Observed MW: 123 kDa |
Isotype: IgG |
Purification: Affinity Purified |
Species Reactivity: Human,Mouse,Rat |
Conjugation: Unconjugated |
Modification: Unmodified |
Constituents: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide |
Research Areas: Signal Transduction |
Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing |
Western blot analysis of CRM1 in 3T3 lysates using CRM1 antibody. |