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DOCK8 Rabbit mAb

Anti-DOCK8 Rabbit Monoclonal Antibody
5/5

$349.00

Cat.#:  N262146

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N262146
Product Name:   Anti-DOCK8 Rabbit Monoclonal Antibody
Synonyms:   MRD2; ZIR8; HEL-205
UNIPROT ID:   Q8NF50
Background:    Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:28028151, PubMed:22461490). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC . Required for CD4+ T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780).
Immunogen:    Recombinant protein of human DOCK8
Applications:    WB,ICC/IF
Recommended Dilutions:    WB: 1/500-1/1000 IF: 1/50-1/200
Host Species:    Rabbit
Clonality:    Rabbit Monoclonal
Clone ID:    R05-7D3
MW:    Calculated MW: 239 kDa; Observed MW: 239 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Human
Conjugation:    Unconjugated
Modification:    Unmodified
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Cardiovascular
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Western blot analysis of DOCK8 in Ramos lysates using DOCK8 antibody.
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