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EID3 Rabbit pAb

Anti-EID3 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S220516

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S220516
Product Name:   Anti-EID3 Rabbit Polyclonal Antibody
Synonyms:   NS4EB; NSE4B; NSMCE4B
UNIPROT ID:   Q8N140 (Gene Accession – NP_001008395 )
Background:    EID3 is highly expressed in testis and shows homology to a region of EID1 implicated in binding to CBP/p300. EID3 acts as a potent inhibitor of nuclear receptor transcriptional activity by a mechanism that is independent of direct interactions with nuclear receptors, including SHP. Furthermore, EID3 directly binds to and blocks the SRC-1 interacting domain of CBP, which has been implicated to act as the interaction surface for nuclear receptor co-activators. Consistent with this idea, EID3 prevents recruitment of CBP to a natural nuclear receptor-regulated promoter.
Immunogen:    Synthetic peptide of human EID3
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 25-100; ELISA: 1000-2000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction, Epigenetics and Nuclear Signaling, Cancer
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human gasrtic cancer tissue using 220516(EID3 Antibody) at a dilution of 1/15(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human gasrtic cancer tissue is first treated with the synthetic peptide and then with 220516(Anti-EID3 Antibody) at dilution 1/15.

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 220516(Anti-EID3 Antibody) at a dilution of 1/15.

In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with synthetic peptide and then with D261639(Anti-EID3 Antibody) at dilution 1/15.
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