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ESR1 Rabbit pAb

Anti-ESR1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S219763

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S219763
Product Name:   Anti-ESR1 Rabbit Polyclonal Antibody
Synonyms:   ER, ESR, Era, ESRA, NR3A1
UNIPROT ID:   P03372 (Gene Accession – NP_000116 )
Background:    This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5′ UTRs and use different promoters.
Immunogen:    Synthetic peptide of human ESR1
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 100-300; ELISA: 1000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction, Epigenetics and Nuclear Signaling, Neuroscience
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human brain tissue using 219763(ESR1 Antibody) at a dilution of 1/76(Cytoplasm, Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human brain tissue is first treated with the synthetic peptide and then with 219763(Anti-ESR1 Antibody) at dilution 1/76.

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 219763(Anti-ESR1 Antibody) at a dilution of 1/76.

In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with synthetic peptide and then with D260314(Anti-ESR1 Antibody) at dilution 1/76.
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