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ID4 Rabbit pAb

Anti-ID4 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S219789

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S219789
Product Name:   Anti-ID4 Rabbit Polyclonal Antibody
Synonyms:   IDB4, bHLHb27
UNIPROT ID:   P47928 (Gene Accession – NP_001537 )
Background:    DNA-binding protein inhibitor ID-4 is a protein that in humans is encoded by the ID4 gene. Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH proteins is dependent on formation of homo- and/or heterodimers. Dominant-negative (antimorph) HLH proteins encoded by Id-related genes, such as ID4, also contain the HLH-dimerization domain but lack the DNA-binding basic domain. Consequently, Id proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins .
Immunogen:    Synthetic peptide of human ID4
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 20-100; ELISA: 1000-5000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling, Signal Transduction
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human esophagus cancer tissue using 219789(ID4 Antibody) at a dilution of 1/20(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human esophagus cancer tissue is first treated with the synthetic peptide and then with 219789(Anti-ID4 Antibody) at dilution 1/20.

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using 219789(Anti-ID4 Antibody) at a dilution of 1/20.

In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with synthetic peptide and then with D260373(Anti-ID4 Antibody) at dilution 1/20.
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