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p300 Rabbit pAb

Anti-p300 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  N225478

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N225478
Product Name:   Anti-p300 Rabbit pAb
Synonyms:   EP300; P300; Histone acetyltransferase p300; p300 HAT; E1A-associated protein p300
UNIPROT ID:   Q09472
Background:    EP300: E1A binding protein p300. This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
Immunogen:    Synthesized peptide derived from the Internal region of human p300.
Applications:    ICC/IF,WB,IHC-F,IHC-P,ELISA
Recommended Dilutions:    WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 ELISA: 1/10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Clone ID:   
MW:    Calculated MW: 264 kDa; Observed MW: 300 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Human,Mouse,Rat
Conjugation:    Unconjugated
Modification:    Unmodified
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Hypoxia Signal Transductionyyyyy Hypoxia-induced
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin-embedded Human breastcancer using p300 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Western blot analysis of p300 in HELA, 293T, 823AV lysates using p300 antibody.
          Publications