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Phospho-beta Arrestin 1 (Ser412) Rabbit mAb

Anti-Phospho-beta Arrestin 1 (Ser412) Rabbit Monoclonal Antibody
5/5

$349.00

Cat.#:  N263151

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N263151
Product Name:   Anti-Phospho-beta Arrestin 1 (Ser412) Rabbit Monoclonal Antibody
Synonyms:   ARB1; ARR1; ARRB1; ARRB1_HUMAN; Arrestin 2; Arrestin beta 1; Arrestin beta-1; Beta-arrestin-1.
UNIPROT ID:   P49407
Background:    Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]
Immunogen:    A synthetic phosphopeptide corresponding to residues surrounding Ser412 of human beta Arrestin 1
Applications:    WB,IHC-P,IP
Recommended Dilutions:    WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20
Host Species:    Rabbit
Clonality:    Rabbit Monoclonal
Clone ID:    R05-6F7
MW:    Calculated MW: 47 kDa; Observed MW: 50 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Human
Conjugation:    Unconjugated
Modification:    Phosphorylated
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Signal Transduction
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin-embedded Human lung cancer using beta Arrestin 1 (Phospho-Ser412) antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Western blot analysis of Phospho-beta Arrestin 1 (Ser412) in A549, MCF-7, U251, HL-60 lysates using Phospho-beta Arrestin 1 (Ser412) antibody.
          Publications