Email: info@neweastbio.com   |  Call: 6109452007

Phospho-CBL (Tyr774) Rabbit mAb

Anti-Phospho-CBL (Tyr774) Rabbit Monoclonal Antibody
5/5

$349.00

Cat.#:  N261727

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N261727
Product Name:   Anti-Phospho-CBL (Tyr774) Rabbit Monoclonal Antibody
Synonyms:   CBL; CBL2; RNF55; E3 ubiquitin-protein ligase CBL; Casitas B-lineage lymphoma proto-oncogene; Proto-oncogene c-Cbl; RING finger protein 55; Signal transduction protein CBL
UNIPROT ID:   P22681
Background:    This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder
Immunogen:    A synthetic phosphopeptide corresponding to residues surrounding Tyr774 of human CBL
Applications:    WB,IP
Recommended Dilutions:    WB: 1/500-1/1000 IP: 1/20
Host Species:    Rabbit
Clonality:    Rabbit Monoclonal
Clone ID:    R07-8A3
MW:    Calculated MW: 100 kDa; Observed MW: 120 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Human,Rat
Conjugation:    Unconjugated
Modification:    Phosphorylated
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Cell Biology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Western blot analysis of Phospho-CBL (Tyr774) in K562, C6, Hela lysates using Phospho-CBL (Tyr774) antibody.
          Publications