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Phospho-KCNQ2/3/4/5 (Thr217/Thr246/Thr223/Thr251) Rabbit pAb

Anti-Phospho-KCNQ2/3/4/5 (Thr217/Thr246/Thr223/Thr251) Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  N225496

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N225496
Product Name:   Anti-Phospho-KCNQ2/3/4/5 (Thr217/Thr246/Thr223/Thr251) Rabbit pAb
Synonyms:   KCNQ2; Potassium voltage-gated channel subfamily KQT member 2; KQT-like 2; Neuroblastoma-specific potassium channel subunit alpha KvLQT2; Voltage-gated potassium channel subunit Kv7.2; KCNQ3; Potassium voltage-gated channel subfamily KQT me
UNIPROT ID:   O43526/O43525/P56696/Q9NR82
Background:    The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.
Immunogen:    The antiserum was produced against synthesized peptide derived from human Kv7.3/KCNQ3 around the phosphorylation site of Thr246. AA range:191-240
Applications:    IHC-P,ELISA
Recommended Dilutions:    IHC: 1/50-1/100 ELISA: 1/10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Clone ID:   
MW:   
Isotype:    IgG
Purification:    Affinity Chromatography
Species Reactivity:    Human,Mouse,Rat
Conjugation:    Unconjugated
Modification:    Phosphorylated
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Neuroscience
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemical analysis of paraffin-embedded Human tonsils using Phospho-KCNQ2/3/4/5 (Thr217/Thr246/Thr223/Thr251) antibody. Sample with blocking peptide on the right.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

EnzymeLinked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phospho-peptide (Phospho-left) and NonPhospho-peptide (Phospho-right), using Kv7.3/KCNQ3 (Phospho-Thr24antibody
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