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TIAM2 Rabbit mAb

Anti-TIAM2 Rabbit Monoclonal Antibody
5/5

$349.00

Cat.#:  N262995

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N262995
Product Name:   Anti-TIAM2 Rabbit Monoclonal Antibody
Synonyms:   STEF; TIAM-2
UNIPROT ID:   Q8IVF5
Background:    Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane . Activates specifically RAC1, but not CDC42 and RHOA.
Immunogen:    Recombinant protein of human TIAM2
Applications:    WB,IHC-F,IHC-P,ICC/IF
Recommended Dilutions:    WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200
Host Species:    Rabbit
Clonality:    Rabbit Monoclonal
Clone ID:    R09-8G7
MW:    Calculated MW: 190 kDa; Observed MW: 190 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Human
Conjugation:    Unconjugated
Modification:    Unmodified
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Signal Transduction
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Western blot analysis of TIAM2 in K562, 293 lysates using TIAM2 antibody.
          Publications